DSIP (Delta Sleep Inducing Peptide ) 2mg/vial


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Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Its aminoacid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, the gene is unknown, raising serious questions regarding the actual existence of this peptide in nature.

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Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stabilityand through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.

Roles in endocrine regulation

  • Decreases basal corticotropin level and blocks its release.
  • Stimulates release of luteinizing hormone (LH).
  • Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Roles in physiological processes

  • Can act as a stress limiting factor.
  • May have a direct or indirect effect on body temperature and alleviating hypothermia.
  • Can normalize blood pressure and myocardial contraction.
  • It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.
  • There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion[24]and suppression of paradoxical sleep, (PS)while some studies show no correlation.Stronger effects on sleep have been noted for the synthesized analogues of DSIP.
  • It may affect human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.